Search:  This Site | People | Departments | Penn State

Home :. News

Archives

You are currently viewing the archive for February 2015
Posted by: mus41 on Feb 23, 2015
Francesco Costanzo
Department of Engineering Science and Mechanics, PSU

Wednesday, March 4, 2015
3:35pm - 4:25pm

114 EES Building

Abstract:
I will present some recent work dealing with the development of numerical approaches for the study of cerebrospinal fluid flow in brain as well as transport of fluid in brain parenchyma. I will discuss the formulation of an immersed finite element method for fluid-structure interaction. I will also present the development of a poroelastic model for the study of the motion of interstitial fluid in brain tissue along with the formulation of a finite element approach for the solution of the resulting partial differential equations.
Posted by: mus41 on Feb 12, 2015
Jeff Tza-Huei Wang
Departments of Mechanical Engineering & Biomedical Engineering, Johns Hopkins University

Wednesday, February 18, 2015
3:35pm - 4:25pm

114 EES Building

Abstract:
Genomic analysis of biomarkers, including genetic markers such as point mutations and epigenetic markers such as DNA methylation, has become a central theme in modern disease diagnosis and prognosis. Recently there is an increasing interest in using confocal single-molecule spectroscopy (SMS) for genomic detection. The driving force not only comes from its ultrahigh sensitivity that allows detection of low-abundance nucleic acids without the need for amplification but also from its potential in achieving high-accuracy quantification of rare targets via single-molecule sorting. Semiconductor quantum dots (QDs) also show a great promise for biomarker analysis. The unique photophysical properties of semiconductor quantum dots (QDs) such as high quantum yield and photostability make them ideal for use as spectral labels and luminescent probes. QDs also make excellent donors to pair with organic dyes in the fluorescence resonance energy transfer (FRET) process due to the features of narrow emission spectra and small Stokes shift. This enables FRET with minimal direct acceptor excitation and donor-acceptor crosstalk, thereby permitting the design of FRET molecular sensors with extremely low intrinsic fluorescence backgrounds necessary for detecting biomolecular targets at low abundance. On the other hand, microfluidic technologies offer an exciting opportunity to realize the use of biomarkers in routine clinical settings via the development of miniaturized diagnostic systems. These platforms may function as portable bench-top environments that dramatically shorten the transition of a bench-top assay into a point-of-care format. We have developed highly sensitive, quantitative and clinically relevant technologies for analysis of genomic markers based on the convergence of SMS, microfluidic manipulations, and quantum dots. Extraordinary performances of these new technologies have been exemplified by analysis of a variety of biomarkers including point mutations, DNA integrity and DNA methylation in clinical samples.
Posted by: mus41 on Feb 5, 2015
Akhlesh Lakhtakia
Department of Engineering Science and Mechanics, PSU

Wednesday, February 11, 2015
3:35pm - 4:25pm

114 EES Building

Abstract
Some published papers are retracted because they contain serious procedural errors that came to light after publications. Intentional errors amount to scientific misconduct. Falsification of data is also an example of scientific misconduct leading to retraction. Lack of proper attribution for passages borrowed from previously published sources is another reason for retraction. Avoidance of institutional oversight over research involving humans and other animals could lead to retraction. Denial of co-authorship, inclusion of a co-author without permission, and failure to obtain acceptance of the complete version of a manuscript from all co-authors are also reasons for retractions. These and other reasons for retractions will be discussed with reference to actual examples. Attendees are requested to bring their laptops.