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The Penn State Center for Neural Engineering is a university-wide Center, bridging the campuses and Colleges of Engineering and Science at University Park, with the College of Medicine at Hershey. It is housed within facilities of the Department of Neurosurgery and the Department of Engineering Science and Mechanics.
The Center is positioned to facilitate and enable collaboration between faculty from the Huck Institutes for the Life Sciences, Materials Research, and Neuroscience Institutes at Penn State, and forms a physical conduit for faculty and students from across the Engineering Departments, the Integrative Biosciences Neuroscience Program, Physics, Mathematics, and Biology, as well as trainees and faculty from Neurosurgery, Neurology, and Psychiatry. The Center has resident core faculty, with a considerable number of faculty Affiliates drawn from University Park and Hershey.
The Center enables the successful conduct of interdisciplinary research and acquisition of funding for projects that individual Penn State scientists could not perform on their own.
The Center for Neural Engineering provides the core facilities to:
Provide core resources in terms of office space, administrative support, computational facilities, laboratories, and faculty customized for carrying out the missions of NIH sponsored Program Project and Center grants.
Provide an extensive series of educational forums each week focusing on whole animal physiology, cellular physiology, dynamical neuroscience, biological control engineering, and a campus-wide Neural Engineering Seminar series.
Develop the intellectual property which will enable Penn State to develop the next generation of smart devices for the clinical treatment of dynamical diseases of the brain, such as Epilepsy and Parkinson’s disease, as well as improved neural prosthetics to replace lost function in the disabled.
To serve as a center for Junior Faculty development at Hershey. Physician-Scientists recruited at Hershey will have office and laboratory space in the Center for Neural Engineering facilities that will be created in the Life Sciences II Building at University Park, where they will spend one or more days per week enabling them to develop their research programs while simultaneously attending to their clinical responsibilities at Hershey.
Presently occupying 3000 square feet of customized space in the Earth-Engineering Sciences Building, the Center will move in 2010 to 22,000 square feet in the new Life Sciences II/Material Science Building. Within this space there will be space for individual investigators, but importantly, there will be substantial shared facilities to meet the above needs. Specifically, there will be several different sizes of conference rooms, with video conference capability to facilitate the interaction with Hershey and other investigators. Significant shared facilities will be created for histology, computerized microscopy, animal behavioral monitoring, and computational resources. Offices are planned for six Hershey faculty, MDs and PhDs, to be in residence at any one time. A novel teaching laboratory will serve as a teaching platform to teach the concepts, hardware, and software of Brain-Machine Interface engineering to advanced undergraduate and graduate students within the Engineering College.
We anticipate that this Center will serve as a model and test bed for serious long-term development of bridges between the strengths of University Park and the College of Medicine campuses.
Key developments from 2006-2008 include:
Established the MD-PhD Track in Engineering Science and Mechanics tailored for the MD-PhD student who seeks to become a Physician-Engineer.
Establishing the Neural Engineering PhD Track in Engineering Science and Mechanics. Core courses from ESC, EMC, BIO, EE, and new Courses include:
E SC 497B Brain Machine Interfaces
E SC 597 Introduction To Neural Engineering: Fundamentals Of Interfacing Wtih Brain
E SC 597A (pending 529) Neural Control Engineering
Crosslisted as PHYS 597A
Establishing the first Brain-Machine Interface Teaching Laboratory in the US, and initiating the first course in this subject (E SC 497B) in the US that we are aware of.
Established the Controls Group and weekly seminar series seeking to bring together the Controls Engineering expertise on campus around biological applications.
We have established 16 IRB and IACUC protocols for human and animal experiments in Neural Engineering.
Established a strong link with Pediatric Neurosurgical colleagues in Mbale, Uganda, with 3 active African IRB protocols seeking to engineer better solutions for image analysis for epilepsy and hydrocephalus, and to seek the bacterial origins of neonatal ventriculitis in that region of rural East Africa.
Funded Pilot projects include
Organized and funded an NIH Sponsored Conference on the Ethics of Neural Prosthetics at PSU
Ongoing Research Projects
Dynamics and Control of Pattern Formation in the Brain
Novel Electrical Field Interface for Neural Prosthetics
Microlesion Effects of Deep Brain Stimulation
Model Based Control of Seizures, Rhythms, and Parkinson’s disease activity
Model Based Brain-Machine Interfaces
Nano-sensing of the Metabolic Microdomain of Seizures
Wave Mechanics of Brain Activity
Computational Modeling of Epileptic Seizures
Computational Modeling of Brain Rhythmicity
Novel Electrode Material Construction
The One-Laptop per ICU Patient Project
Use of CT as a Substitute for MRI in the evaluation of Epilepsy in sub-Saharan Africa
Segmentation of Bran and Fluid from CT and MRI scans
DNA Forensics to Identify the Agents Responsible for Neonatal Ventriculitis in East Africa
Future Developments
The facilities in new Life Science II – Material Science Building 3rd floor W will be one of the premier facilities in the world for conducting Neural Engineering on a systems level. The proximity to Materials Sciences gives us unusual opportunity for synergistic work on the properties of the Material Brain. The 22,000 square feet are custom designed for up to 12 faculty including
Brain Machine Interface teaching and research laboratory
Electrical equipment construction and testing
Laser optical imaging suite
Open space for multiple neurophysiology experimental stations
Behavioral maze testing
Confocal microscopy
Computerized microscopy: Neurolucida and Stereology
Histology
Machine Shop
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