Research Associate
Engineering Science and Mechanics
212 Earth-Engineering Sciences Building
University Park, PA 16802
(814) 865-2481
(815) 865-9974 Fax
E-Mail sus28(a)psu.edu

http://www.cne.psu.edu
http://www.esm.psu.edu

• Ph.D. Honors, Chemical Engineering, University of Kansas, 1999.
• M.S., Chemical Engineering, University of Kansas, 1995.
• B.E., Chemical Engineering, Annamalai University, 1991.

Relevant training

• MBL Neuroinformatics Course, Woods Hole, MA Aug 11-26, 2007.

Honors

• Epilepsy Foundation of America Postdoctoral Research Fellowship, 2009.
• Travel grant, SAND4 - Systematic Analysis of Neuronal Data Workshop, Pittsburgh 2008.
• Tuition grant, MBL Neuroinformatics course 2007.
• Outstanding Ph.D. Award, Chemical & Petroleum Engineering, University of Kansas, 2000.
• Nominated to Phi Beta Delta International Honor Society, University of Kansas, 1997.

Interests

• Neuroinformatics - Analysis of brain and related signals.
• Epilepsy - seizure detection, prediction and control using electrical stimulation; stochastic models of seizure recurrence, state dependence and evolution; assessment of treatment efficacy; acute and chronic animal models, clinical studies.
• Brain state dynamics - automated state discrimination; sleep architecture.
• Medical image analysis - mathematical morphology; mammographic assessment of breast cancer risk.

Publications

• SUNDERAM S, Chernyy N, Peixoto N, Mason J, Weinstein SL, Schiff SJ and Gluckman BJ. Seizure Entrainment with Polarizing Low-Frequency Electric Fields in a Chronic Animal Epilepsy Model. J Neural Eng, 6: 046009 (15pp), 2009. (doi: 10.1088/1741-2560/6/4/046009)
• SUNDERAM S, Osorio I and Frei MG. Epileptic Seizures Are Temporally Interdependent Under Certain Conditions. Epilepsy Research, 76: 77-84, 2007.
• SUNDERAM S, Chernyy N, Peixoto N, Mason JP, Weinstein SL, Schiff SJ and Gluckman BJ. Improved Sleep-Wake and Behavior Discrimination Using MEMS Accelerometers. J Neuroscience Methods, 163: 373-383, 2007.
• SUNDERAM S, Chernyy N, Mason J, Peixoto N, Weinstein SL, Schiff SJ and Gluckman BJ. Seizure Modulation With Applied Electric Fields in Chronically Implanted Animals. Proc. 28th IEEE EMBS Annual Intl. Conf., p1612-15, 2006.
• Osorio I, Frei MG, SUNDERAM S, Giftakis J, Bhavaraju NC, Schaffner SF, Wilkinson SB. Automated Seizure Abatement in Humans using Electrical Stimulation. Annals of Neurology, 57:258-268, 2005.
• SUNDERAM S and Osorio I. Mesial Temporal Lobe Seizures May Activate Thermoregulatory Mechanisms in Humans: An Infrared Study of Facial Temperature. Epilepsy and Behavior, 4: 399-406, 2003.
• SUNDERAM S, Osorio I, Watkins JF, Wilkinson SB, Frei MG and Davis RE. Vagal and Sciatic Nerve Stimulation have Complex Time-Dependent Effects on Chemically Induced Seizures: A Controlled Study. Brain Research, 918(1-2): 60-66, 2001.
• Osorio I, Frei MG, Manly BFJ, SUNDERAM S, Bhavaraju NC and Wilkinson SB. An Introduction to Contingent (Closed-Loop) Brain Electrical Stimulation for Seizure Blockage, to Ultra-short-term Clinical Trials, and to Multidimensional Statistical Analysis of Therapeutic Efficacy. J Clin Neurophysiol, 18(6):533-544, 2001.
• SUNDERAM S, Osorio I, Frei MG and Watkins JF. Stochastic Modeling and Prediction of Experimental Seizures in Sprague-Dawley Rats. J Clin Neurophysiol, 18(3):275-282, May 2001.

In preparation

• Osorio I, Manly BFJ, SUNDERAM S, Frei MG. Contingent Electrical Stimulation Significantly Reduces Seizure Frequency in Pharmaco-resistant Human Epilepsy (revisions pending, Epilepsy Research).

Abstracts (selected)

• Chernyy N, SUNDERAM S, Mason JP, Peixoto N, Weinstein SL, Schiff SJ and Gluckman BJ. Seizure modulation with applied electric fields in chronically implanted animals. AES 61st Annual Meeting, San Diego, CA, Dec 2006.
• SUNDERAM S, Chernyy N, Peixoto N, Mason J, Weinstein SL, Schiff SJ and Gluckman BJ. Characterization of the chronic hippocampal tetanus toxin model of temporal lobe epilepsy. SFN Annual Meeting, Atlanta, GA, Oct 2006.
• Peixoto N, Parekh R, Chernyy N, Mason J, SUNDERAM S, Schiff SJ and Gluckman BJ. Acute biofouling in implanted iridium oxide film electrodes. SFN Annual Meeting, Atlanta, GA, Oct 2006.
• Mason JP, Peixoto N, SUNDERAM S, Parekh R, Weinstein SL, Schiff SJ and Gluckman BJ. Neurodegeneration due to electrode implantation in freely behaving animals. AES Annual Meeting, Washington D.C., 2005.
• SUNDERAM S, Peixoto N, Chernyy N, Mason JP, Weinstein SL, Schiff SJ and Gluckman BJ. Sleep-wake stage and behavior discrimination in rats using a combination of EEG and head acceleration measurements. SFN Annual Meeting, Washington D.C., Nov 2005.
• Chernyy N, Peixoto N, Mason JP, SUNDERAM S, Weinstein SL, Schiff SJ and Gluckman BJ. Multichannel recording and isolated stimulation system for chronic electric field stimulation in rats. SFN Annual Meeting, Washington D.C., Nov 2005.
• Peixoto N, Chernyy N, Weinstein SL, Parekh RS, Mason JP, SUNDERAM, Schiff SJ and Gluckman BJ. Electrodeposited iridium oxide electrodes for low frequency non-pulsatile stimulation in chronically implanted animals. NINDS Neural Interfaces Workshop, Bethesda, Maryland, Sept 2005.
• SUNDERAM S, Frei MG and Osorio I. Are seizures temporally inter-dependent? Minisymposium on Seizure Dynamics, SIAM Conference on Applications of Dynamical Systems, Snowbird, Utah, May 22-26 2005.
• SUNDERAM S and Kimler BF. Development of Software for Automated Measurement of Mammographic Breast Density. Kansas City Area Life Sciences Research Day, June 4, 2004.
• Osorio I, Frei MG, SUNDERAM S, Giftakis J, Bhavaraju NC, Schaffner SF, Wilkinson SB. Automated Seizure Abatement in Humans using Electrical Stimulation. AES Annual Meeting, New Orleans, Dec. 2004.
• Johnson AM, Frei MG, SUNDERAM S, Asuri S, Osorio I. Application of the Intrinsic Timescale Decomposition (ITD) algorithm to EEG seizure detection. Epilepsia, 42(S7):37, 2001.
• Osorio I, Frei MG, Wilkinson SB, SUNDERAM S, Bhavaraju NC, Graves N, Schaffner SF, Peters T, Johnson AM, DiTeresi CA, Ingram J, Nagaraddi V, Overman J, Kavalir MA and Turnbull M, Seizure Blockage with Automated “Closed-Loop” Electrical Stimulation: A Pilot Study. Epilepsia. 42(S7):207, 2001.
• Peters T, Frei MG, Bhavaraju NC, SUNDERAM S and Osorio I. Network System for Automated Seizure Detection and Stimulation. Epilepsia. 42(S7):40, 2001.
• Ingram J, SUNDERAM S, Frei MG, Osorio I, Autonomic Regulation During Complex Partial Seizures: A Thermographic Study. Epilepsia. 41(S7):59, 2000.
• SUNDERAM S, Watkins III JF, Frei MG and Osorio I. A Stochastic Analysis of Ictal-Interictal Transitions During Experimental Seizures: Seizure Duration Depends on the Duration of Preceding Ictal and Interictal States Epilepsia. 41(S7):49, 2000.
• DiTeresi CA, Thompson M, Frei MG, SUNDERAM S and Osorio I. Loss of Function During Partial Seizures: A Quantitative Study in Humans. Epilepsia. 41(S7):237, 2000.
• SUNDERAM S, Olney BW and Southard MZ. Evaluation of Surgical Limb Lengthening Through Radiographic Absorptiometry. AIChE, Annual Meeting, 1998.
• SUNDERAM S and Southard MZ. Oxygen Transport and Mixing Considerations for Fragile Mammalian Cell Culture in an Airlift Reactor. AIChE, Annual Meeting, 1995.
• Mugeraya G, SUNDERAM S and Modak JM. Effect of pH on the Growth Kinetics of Thermophilic Fungus T. Aurantiacus. 45th Annual Session of Indian Institute of Chemical Engineers, Manipal, India, Dec. 19-22, 1992.

Grants
As PI or Co-PI

• Towards a Behavioral Index of Seizure Susceptibility (NIH/NINDS R03 - 5/2009 - 4/2011). PI: Sridhar Sunderam, Ph.D., The Pennsylvania State University.
• Software Tool for Seizure Analysis and Prediction (NIH/NINDS Ph I SBIR - 5/2003 - 11/2004). PI: Sridhar Sunderam, Ph.D., Flint Hills Scientific, Lawrence, Kansas.
• Improved Software for Assessment of Breast Density (Kansas City Life Sciences Institute seed grant: 11/2003 - 11/2004). Co-PI: Sridhar Sunderam, Ph.D. (with Bruce F. Kimler, Ph.D. of KUMC), Flint Hills Scientific, Lawrence, Kansas.

As an investigator

• Perturbative Seizure Prediction and Detection of a Preseizure State (NIH/NINDS R01: 5/2009-4/2013). PI: Bruce J. Gluckman, Ph.D., The Pennsylvania State University.
• Electric Field as a Novel Neuronal Interface (NIH/NIBIB R01: 6/2003-5/2007). PI: Bruce J. Gluckman, Ph.D., George Mason University.
• Real Time Automated Seizure Prediction and Detection (NIH/NINDS Ph I SBIR 9/1999-9/2001). PI: Aaron M. Johnson, Flint Hills Scientific, Lawrence, Kansas.
• Software and Devices for Real-Time Seizure Detection (NIH/NINDS Ph I & II SBIR 9/1995-8/2001). PI: Mark G. Frei, Ph.D., Flint Hills Scientific, Lawrence, Kansas.

Experience

• 8/2006-present Research Associate, Center for Neural Engineering, Engineering Science and Mechanics, Penn State University. Supervisor: Bruce J. Gluckman, Ph.D.
• 2/2005-7/2006 Research Assistant Professor, Center for Neural Dynamics, George Mason University. Supervisor: Bruce J. Gluckman, Ph.D.
• 12/2000-1/2005 R & D Engineer, Flint Hills Scientific, Lawrence, Kansas.
• 12/1998-10/2000 Research Associate, Flint Hills Scientific, Lawrence, Kansas.
• 1993-98 Graduate Research/Teaching Assistant, University of Kansas.
• 1991-93 Research Assistant, Indian Institute of Science, Bangalore.

Activities

• Senior Member, American Institute of Chemical Engineers (since 1993)
• Member, Society for Neuroscience (since 2005)
• Member, International Brain Research Organization (since 2005)
• Member, Indian Institute of Chemical Engineers (1991-1993)
• Ad hoc reviewer: IEEE Trans BME, J Neuroscience Methods, Annals of Biomedical Engineering, Medical Physics, Computers in Biology and Medicine.